Oshoala was introduced just before the start of the second half but fired blanks as Lyon sealed a record-extending eight Champions League title.
Recall Lyon thumped Barcelona 4-1 when both teams clashed in the final on 2019.
In Saturday’s final played inside Juventus stadium, Lyon got off to a great start after going 1-0 ahead in the sixth minute through Amandine Henry.
In the 26th minute Ada Hegerberg made it 2-0 before Catarina Macario added the third goal 10 minutes after Lyon’s second goal.
With four minutes left in the first half Barcelona pulled a goal back off Alexia Putellas which was only a consolation.
Lyon have now won six of the last seven Champions League finals.
By James Agberebi
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